NORTH Study

The North Study, a national retrospective case series on the management of disseminated NOn-tubeRculous mycobacTerial infection in adults living with HIV, is a UK-wide, retrospective, descriptive, case series of disseminated NTM infection in people living with HIV treated in the era of modern antiretroviral therapy (ART).

Despite decreasing incidence due to widespread availability and early use of more efficacious and robust ART, disseminated NTM infection remains an important cause of hospitalisation, morbidity, and mortality in people living with HIV. However, the evidence that informs current practice comes from when ART was not as widely available or robust. Evidence is limited to inform recommendations on treatment duration and practice varies hugely, with patients often treated for many months.

The NORTH study aims to recruit patients living with HIV and disseminated NTM infection over the last 10 years and describe adverse outcomes and frequency of relapse according to different NTM treatment durations. It aims to inform recommendations on treatment duration and reliable surrogate markers to inform individual decisions on treatment. 
We are now open to sites interested in taking part.

 

If you are interested in getting involved, please get in touch with the Chief Investigator, Cristina Fernandez, via email.