Andres Floto is a Wellcome Trust investigator and Professor of Respiratory Biology in the Molecular Immunity Unit of the University of Cambridge (based at the Medical Research Council Laboratory of Molecular Biology), Research Director of the Cambridge Centre for Lung Infection at Royal Papworth Hospital, and Director of the UK Cystic Fibrosis (CF) Innovation Hub. 

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His basic research is focused on understanding how macrophages interact with bacteria, how bacteria evolve during chronic infection and transmission, and how forward and reverse genetics can be combined with fragment-based drug discovery to develop novel antibiotics and host-directed therapies.

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His clinical research is centred around tackling chronic inflammation in CF and non-CF bronchiectasis, treating non-tuberculous mycobacteria (NTM), and using graphical model-based machine learning to understand and predict pulmonary exacerbations in CF. 

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Clinically he specialises in the management of NTM, CF, non-CF bronchiectasis, and recurrent chest infections. He co-chairs the British Thoracic Society NTM guidelines committee, the joint US CF Foundation-European CF Society (ECFS) NTM Guidelines Group, and the ECFS working group on NTM.